2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
- Product Name
- 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
- CAS No.
- 194085-75-1
- Chemical Name
- 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
- Synonyms
- YKP 509;RWJ 333369;Carisbamate;JNJ 10234094;(S)-Carisbamate;CarisbaMate (RWJ-333369);2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE;[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate;1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-;1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
- CBNumber
- CB11474577
- Molecular Formula
- C813CH8D2Cl15NO3
- Formula Weight
- 215.63
- MOL File
- 194085-75-1.mol
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Property
- Melting point:
- 131-132°C
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 23514
- Product name
- Carisbamate
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 23514
- Product name
- Carisbamate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $218
- Updated
- 2024/03/01
- Product number
- C183510
- Product name
- (S)-Carisbamate
- Packaging
- 5mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- API0009416
- Product name
- CARISBAMATE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $315
- Updated
- 2021/12/16
- Product number
- X3698
- Product name
- (S)-Carisbamate
- Packaging
- 1mg
- Price
- $340
- Updated
- 2021/12/16
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Chemical Properties,Usage,Production
Description
Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.
Uses
Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.
Uses
Labelled Carisbamate; it is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizu re models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.
Definition
ChEBI: Carisbamate is an organochlorine compound.
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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